Nasal Delivery of Proteins and Peptides

Nasal Delivery of Proteins and Peptides

Recent years have shown that nasal route can be a potential route for the systemic delivery of protein/peptide drugs as it has a considerably large absorption area (150cm2) which is highly vascularized and has permeability similar to or higher than the small intestinal mucosa. Nasal delivery of protein/peptide drugs also offers other benefits such as ease of administration, noninvasive administ...

Formulation and Delivery of Proteins and Peptides

Inhalation delivery of therapeutic peptides and proteins.

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Natural peptides and proteins: potent tyrosinase inhibitors

Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...

Prodrugs of peptides and proteins for improved formulation and delivery.

This paper aims to review the existing literature on the use of prodrugs to circumvent some of the difficulties associated with the formulation, systemic delivery, and rapid clearance of peptide and protein therapeutic agents. Understanding the basic elements involved in effective delivery and formulation of peptides and proteins is both intellectually challenging and enormously important. The ...